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KMID : 0385520100230010054
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Analytical Science & Technology
2010 Volume.23 No. 1 p.54 ~ p.59
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Simultaneous determination of parabens in cosmetics by LC/MS
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Park Gyo-Beom
Lee Sueg-Geun
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Abstract
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The simultaneous analysis of parabens in cosmetic samples was carried out by LC/MS. The cosmetic samples are directly dissolved in methanol and filterated using 0.45 ㎛ filter. The methanol-water was used for the mobile phase of gradient conditions. An Extend C18 reverse-phase column and the selected ion monitoring (SIM) mode were applied. The analysis results of LC/MS showed good linearity with correlation coefficient of r²=0.9993 in the range of 0.05 to 10 ㎍/mL and detection limit of 0.01 ㎍/mL.
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KEYWORD
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paraben, LC/MS
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